Brain Cancer Treatment Market Size 2022 | Share, Growth, world Analysis Report 2032 by DelveInsight | corporations - Bayer, Diffusion Pharmaceuticals, VBL Therapeutics, AstraZeneca, DNAtrix
trends, key pharmaceutical companies operating within the Brain Cancer market, recent approvals, expected launches, Brain Cancer pipeline therapies, compensation policies, and competitive analysis of rising therapies.
a number of the very important points from the Brain Cancer Market report:
• The marketed medication in the Brain Cancer market landscape embodies Avastin (Genentech) and Temodar/Temodal (Merck). However, each drug has reached its patent expiration and its generics are floating in the market.
• Generics have compacted the Brain Cancer market value, however, these are efficient and persuade be a bonus to patients.
• The expected launch of potential Brain Cancer pipeline therapies, as well as Regorafenib, Trans atomic number 11 Crocetinate, Ofranergene obadenovec (VB-111), Durvalumab, Tasadenoturev (DNX-2401) + Pembrolizumab, VAL-083 (Dianhydrogalactitol), ONC201, Selinexor (KPT-330), VBI-1901, Paxalisib (GDC-0084), AV-GBM-1, MDNA55, pp65-shLAMP DC with GM-CSF (ITI-1000), INO-5401+ INO-9012 + cemiplimab (REGN2810), Eflornithine + Lomustine, Everolimus (RAD001) and Ad-RTS-hIL-12 + Veledimex ± Cemiplimab-Rwlc, is anticipated to feature to the revenue generation within the Brain Cancer market in the returning years.
• Out of all the rising therapies, candidates that incontestable promising ends up in the late- or clinical test stage of clinical development embody Ofranergene obadenovec (VB-111; VBL Therapeutics), Trans atomic number 11 Crocetinate (Diffusion Pharmaceuticals), Eflornithine (Orbus Therapeutics), and Regorafenib (Bayer).
• Orbus therapeutics' Eflornithine is the sole medical care below analysis exclusively for continual dysplasia astrocytoma (AA) whereas the bulk of different Brain Cancer therapies within the pipeline is being investigated for GBM.
• The emerging Brain Cancer pipeline therapies conjointly comprise budding factor therapies, i.e., Ofranergene obadenovec (VBL Therapeutics) and Ad-RTS-hIL-12 together with Veledimex (Ziopharm) in conjunction with four vaccine/immunotherapy candidates like VBI-1901, AV-GBM-1, and ITI-1000 (pp65 DC Vaccine), Tasadenoturev (DNX-2401) by VBI Vaccines, Aivita Biomedical, Immunomic Therapeutics, and DNAtrix, respectively.
• Discoveries of isocitrate dehydrogenase (IDH) mutation, co-deletion of the short arm of body one and also the long arm of chromosome nineteen (1p19q), O6-methylguanine-DNA methyltransferase (MGMT) factor promoter methylation, and simple protein H3-K27M mutation have junction rectifier to additional robust|an improved} understanding of the molecular aberrations related to Brain Cancers.
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A Brain Cancer also referred to as an Associate in Nursing intracranial tumor, or central systema nervosum (CNS) tumormaybebe a cluster of diseases that share the common link of abnormal development of mass lesions within the brain, spinal cord, or its coverings. Symptoms of Brain Cancer are often general or specific and vary relying upon the situation of the Brain Cancer. General symptoms embody headaches, seizures, temperament or memory changes, nausea or vomiting, fatigue, drowsiness, sleep problems, memory problems, and changes in the ability to run or perform daily activities. whereas specific symptoms include pressure or headache close to the tumor, loss of balance and difficulty with fine motor skills, changes in judgment, partial or complete loss of vision, and changes in speech, hearing, memory, or emotional state.
There are over a hundred and fifty identified, completely different Brain Cancers as well as Pilocytic Astrocytoma, Diffuse Astrocytoma, dysplasia Astrocytoma, Oligodendrogliomas, brain tumor Multiforme (GBM), Diffuse midplane brain tumor (Earlier referred to as DIPG), among others.
Brain Cancer will comprise 2 main groups, i.e., Primary Brain Cancer and pathologic process Brain Cancer, on the premise of the unfolding of the tumor cells. Primary Brain Cancer is often inferior (grows slowly) or finest (grows rapidly); interstitial tissue (composed of glial cells) or non-glial (developed on or within the brain's structures, as well as nerves, blood vessels, and glands); and malignant or benign.
in keeping with DelveInsight's medicine analysis, the whole Brain Cancer incident population in the 7MM was calculable to be 60,246 in 2020, which is anticipated to grow by 2032. Further, it had been determined that males accounted for optimum Brain Cancer incident cases as compared to women.
The Brain Cancer market insights report offers historical as well as forecasted Brain Cancer epidemiology coverage in the 7MM from 2019 to 2032 segmented into:
• Total Primary Brain Cancer Incidence
• Grade-specific Brain Cancer Incidence
• Type-specific Brain Cancer Incidence
• Gender-specific Brain Cancer Incidence
• Age-specific Brain Cancer Incidence
Want to know more about changing Brain Cancer epidemiological trends? Contact @ Brain Cancer Market Landscape - https://www.delveinsight.com/report-store/brain-cancer-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr
Brain Cancer Treatment Market
Brain Cancers, especially High-grade gliomas are hard-to-treat tumors owing to the inability of available treatment regimens to remove the whole of the tumor due to their resistance to radiotherapy and chemotherapy.
At the moment, there exists no ideal treatment. It is quite challenging to effectively develop one treatment that can target every tumor cell. Thus, the present Brain Cancer treatment landscape offers a combination of several of the available approaches including surgery, chemotherapy, radiation, or stereotactic radiosurgery followed by additional/adjuvant treatments, such as chemotherapy or radiation therapy, after surgery.
The Brain Cancer treatment market offers first-line treatment involving Surgery ± Radiation Therapy/ Chemotherapy, Temozolomide + Radiation Therapy (RT) or Radiation Alone- Maintenance therapy, and Temozolomide Monotherapy. The second-line treatment for Brain Cancer includes Bevacizumab Monotherapy, Bevacizumab Combination Therapy, Temozolomide (Both as Combination and Monotherapy), and Other Systemic Therapies (Concomitant and Adjuvant Chemotherapy agents).
However, despite the availability of several combinations of therapies, the overall survival rate remains low and the chances or rates of recurrence are tremendously high. The Brain Cancer treatment market lacks an effective strategy to tackle Brain Cancers. Thus, moving ahead, the Brain Cancer market is in dire need of therapies specific for the anaplastic form of tumors.
Brain Cancer Market
Key players such as Bayer, Diffusion Pharmaceuticals, VBL Therapeutics, AstraZeneca, DNAtrix, Kintara Therapeutics, Oncoceutics, KaryoPharm, VBI Vaccines, Kazia Therapeutics, Aivita Biomedical, Medicenna Therapeutics, Immunomic Therapeutics, Inovio Pharmaceuticals, Orbus Therapeutics, Novartis, Ziopharm, and others are actively engaged in developing treatments and advancing Brain Cancer market.
In the 7MM, the United States accounted for the maximum Brain Cancer market share worth USD 986.0 Million in 2020 in comparison to EU5 (Italy, Germany, France, Spain, and the UK) and Japan, respectively. The market share is further expected to increase during the forecast period 2022-32.
Key Brain Cancer Pipeline Therapies
• Trans Sodium Crocetinate
• Regorafenib
• Ofranergene obadenovec (VB-111)
• Durvalumab
• Tasadenoturev (DNX-2401) + Pembrolizumab
• VAL-083 (Dianhydrogalactitol)
• ONC201
• Selinexor (KPT-330)
• VBI-1901
• Paxalisib (GDC-0084)
• AV-GBM-1
• MDNA55
• pp65-shLAMP DC with GM-CSF (ITI-1000)
• INO-5401+ INO-9012+Cemiplimab (REGN2810)
• Eflornithine + Lomustine
• Everolimus (RAD001)
• Ad-RTS-hIL-12 + Veledimex ± Cemiplimab-Rwlc
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Brain Cancer Market Forecast
The parameters such as the aging population demonstrate that the world is expected to reach a demographic dividend, which is expected to add to the potential patient pool of Brain Cancers.
Besides medical advancements, ever-evolving research, better diagnostic tests, the emergence of novel surgical approaches, improved radiotherapy techniques, and the development of novel systemic therapies are principal factors acting as fuel to drive the engine of the Brain Cancer market size forward.
It has also been witnessed over past years that a significant number of organizations, government initiatives, and non-profit organizations have been in place to heighten awareness regarding Brain Cancers. Moreover, several foundations and organizations are offering reimbursement policies and financial assistance to patients and their caretakers to tone down the cost burden.
A lack of competitors in Anaplastic astrocytoma offers a substantial market opportunity to pharma titans as well as emerging players to explore the respective domain and develop tumor-targeting therapies. With no available cure, the Brain Cancer market landscape is nothing short of a bright opportunity for the advent of effective novel therapies and targeted treatments. Although there is no denying that there exist snags and unpredictable factors such as poor pharmacokinetic properties, the emergence of resistance pathways, complex intratumoral heterogeneity, and suboptimal clinical trial design, that may lead to drug failures. However, the fundamentals of the Brain Cancer market are expected to transform in the foreseeable future due to improved diagnostic methodologies, increased knowledge of the disease, increased expenditure on healthcare around the world, and the expected launch of emerging therapies.
Here's What Analysts Say
The Brain Cancer market has been witnessing substantial advances in the understanding of the molecular aberrations found in malignant gliomas. The key discoveries of isocitrate dehydrogenase (IDH) mutation, codeletion of the short arm of chromosome 1 and the long arm of chromosome 19 (1p19q), O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation, and histone H3-K27M mutation, regarding the pathophysiology of the indication, can prove beneficial in the development of targeted therapies.
Thus, pharma companies exploring the waters of the Brain Cancer market are targeting specific mutations, such as VAL-083 (dianhydrogalactitol), Durvalumab, and ONC201. Out of these Brain Cancer pipeline therapies, VAL-083 and Durvalumab target the unmethylated MGMT form of glioblastoma while ONC201 targets the H3 K27M-mutant form of glioma.
Talking about patient-centric approaches, emerging therapies can also be sorted according to the patient's preference for the route of administration. For instance, patients mostly prefer oral and/or intravenous administration of drugs as compared to intratumoral administration owing to easier as well as painless administration. Besides convenience, intratumoral drug administration is also limited by poor diffusion of drugs through the brain interstitium.
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Scope of the report
• Coverage: 7MM (The US, EU5, and Japan)
• Study Period: 2019-32
• Key Companies: Bayer, Diffusion Pharmaceuticals, VBL Therapeutics, AstraZeneca, DNAtrix, Kintara Therapeutics, Oncoceutics, KaryoPharm, VBI Vaccines, Kazia Therapeutics, Aivita Biomedical, Medicenna Therapeutics, Immunomic Therapeutics, Inovio Pharmaceuticals, Orbus Therapeutics, Novartis, Ziopharm among others.
• Key Pipeline Therapies: Trans Sodium Crocetinate, Regorafenib, Ofranergene obadenovec (VB-111), Durvalumab, Tasadenoturev (DNX-2401) + Pembrolizumab, VAL-083 (Dianhydrogalactitol), ONC201, Selinexor (KPT-330), VBI-1901, Paxalisib (GDC-0084), AV-GBM-1, MDNA55, pp65-shLAMP DC with GM-CSF (ITI-1000), INO-5401+ INO-9012+Cemiplimab (REGN2810), Eflornithine + Lomustine, Everolimus (RAD001) among others.
• Market Segmentation: By Geography, By Brain Cancer Therapies
• Analysis: Comparative and conjoint analysis of Chronic Pain emerging therapies
• Tools used: SWOT analysis, Porter's Five Forces, PESTLE analysis, BCG Matrix analysis methods.
• Case Studies
• KOL's Views
• Analyst's Views
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Table of Contents
1 Key Insight
2 Executive Summary
3 Brain Cancer Market Overview at a Glance
4 Disease Background and Overview: Brain Cancer
5 Recognized Establishments
6 Brain Cancer Treatment
7 National Comprehensive Cancer Network (NCCN) Guidelines for Central
Nervous System Cancers
8 Neurological and vascular complications of primary and secondary brain
tumors: EANO-ESMO Clinical Practice Guidelines for prophylaxis, diagnosis, treatment, and follow-up
9 NICE Guidelines: Brain Cancers (primary) and brain metastases in adults
10 Brain Cancer Treatment Algorithm
11 Brain Cancer Epidemiology and Patient Population
12 Country-wise Brain Cancer Epidemiology of Brain Cancers
13 Unmet Needs in the Brain Cancer Market
14 Brain Cancer Marketed Drugs
15 Brain Cancer Emerging Drugs
16 Brain Cancer Market Access and Reimbursement
17 Case Reports
18 Brain Cancer Market Drivers
19 Brain Cancer Market Barriers
20 SWOT Analysis
21 KOL Reviews
21 Appendix
22 DelveInsight Capabilities
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